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Some heavy metals, such as arsenic, silver and gold can combine with melanin, causing characteristic colorations.

They displace copper from its active center, causing depigmentation. The most classic metal that causes depigmentation for this reason is mercury.

As the temperature decreases, melanogenesis is stimulated.

Oxidants lighten melanin, but strong oxidants, such as hydrogen peroxide or hydroquinone, cause depigmentation of the hair.