Question: Potential near a protein. Adapted from Problem 9 . 8 Physical Biology of the cell, Phillips et al . Consider a protein sphere with a
Potential near a protein. Adapted from Problem Physical Biology of the cell, Phillips et al
Consider a protein sphere with a radius of nm and charge Q e in an aqueous solution of c M NaCl at C Consider the small ions as point charges and use the linear approximation to the PoissonBoltzmann equation.
a Derive an expression for the potential V r of a charge sphere in a salty solution. Assume that the electrical potential at distance r from the center of a charged sphere is:
Ar
Vr eD
r where A is constant and D the Debye length.
Determine the constant A by computing the electric field from the potential and set it equal to ER Q
R
b What is the surface potential of the protein in units kBTe
c What is the concentration of Naions and of Cl ions at the surface of the protein?
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