Question: Problem 1 (continued): B) You need to conjugate the RCK peptide shown below, without binding to or modifying the peptide side chain functional groups in
Problem 1 (continued): B) You need to conjugate the "RCK" peptide shown below, without binding to or modifying the peptide side chain functional groups in any way, to a water soluble polymer containing only carboxylic acid groups. You need to conjugate a small number of peptides (for example, 5 or fewer) to each polymer chain with stable (permanent) linkages (you need linker molecules!) and avoid coupling of the peptides to themselves, or coupling of the polymers to themselves. Coupling of the peptide must be through the C-terminal carboxylate group. HS HO HN N OH H -+ HN + NH. HN H N carboxylic acid 2 polymer RCK peptide n = 100
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