Question: Problem #2 (Excedrin Tablets, Two-Active Assay) The pharmaceutical product Excedrin, which contains Acetaminophen and Caffeine, is compounded in the dosage form of compressed tablets. The
Problem #2 ("Excedrin Tablets, Two-Active Assay") The pharmaceutical product Excedrin, which contains Acetaminophen and Caffeine, is compounded in the dosage form of compressed tablets. The Label claims per tablet 325 mg of Acetaminophen and 65 mg of Caffeine. In the Quality Control testing of this product by HPLC the chemist has determined that the Average Tablet Weight was 0.4502 g. The TABLETS were then turned into a fine powder, an arbitrary portion of 484.9 mg of this powder, accurately weighed, was transferred to a 100 mL volumetric flask and the volume made to mark with the appropriate diluent. The STANDARD was prepared by transferring 349.2 mg of Acetaminophen and 62.0 mg of Caffeine standards to a 100 mL volumetric flask and making the volume to the mark with the appropriate diluent The recorded chromatographic peak areas were as follows: Chromatographic Peak Acetaminophen Caffeine Standard Chromatogram 3200 645 Sample Chromatogram 3500 650 Does the product pass the acceptance criterion %Label Claim between 90.0% and 110.0% for both Acetaminophen and Caffeine
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