Question $10(3$ points$)$

The two homologs of chromosome $11$ in a sample of normal tissue from a cancer patient exhibit synteny across their entire lengths, as expected. However, the two homologs of chromosome $11$ in a cancer from this same individual exhibits a substantial disruption of the normal synteny. What might this finding mean about the cancer from this individual? Pick one answer.

A$.$ It suggests that there an elevated rate of chromosome non$-$disjunction in the cancer

B$.$ It suggests that there may be a defect in mismatch repair in the cancer

C$.$ It suggests that chromothripsis has occurred in cells leading to the cancer

D$.$ It suggests that genome tetraploidization has occurred in the cancer

A

B

C

D