Question 2: Misclassification Bias (15 points)

Chang et al. in 2005 examined the association between a family history of hematopoietic cancer on an individual's risk of lymphoma in Sweden. In this study, the investigators validated self-report of a family history by searching for family members' diagnosis in the Swedish Cancer Registry and examined whether the validity of self-report differed between cases and controls. Use the information contained in the tables below to answer the accompany questions:

Assuming the following table displays the true distribution of exposure among cases and controls, construct a new table with misclassification of exposure if sensitivity and specificity are 60% and 98% among cases; and 38% and 99% among the controls respectively.

True Distribution
	Cases	Control
Family history	56.7	37.1
No family history	1148.3	1189.9

1. Compute the true