> Question 23 10 pts You discovered a potential new drug molecule, which binds to its target with a binding free energy of -41.0 kJ/mol at 37 C. You are performing additional experiments in order to improve the binding affinity of the drug. Select all of the possible modifications that could improve binding A phenyl group at another site of the drug increases the association constant by a factor of 5 A You engineer a new hydrogen bond to be formed between the drug and the target. The addition of an alcohol function in another side of the drug molecule reduces the dissociation constant of the drug-target complex by a factor of 10 The addition of a methyl group at one specific site of the drug molecule results in a binding free energy of -40.5 kJ/mol