Question 23 ( 6 points) Two domains on the adaptor protein GRB2 are shown. Identify the type of each domain and the protein substrate these two domains bind to in the EGFR signaling pathway. 3) Tvpe of domain? 1) SH3 domain, 2) Shc protein, 3) SH2 domain, 4) EGFR 1) SH3 domain, 2) IRS protein, 3) SH2 domain, 4) EGFR 1) SH2 domain, 2) SOS protein, 3) SH3 domain, 4) GPCR 1) SH2 domain, 2) SOS protein, 3) SH3 domain, 4) TNFR 1) SH3 domain, 2) SOS protein, 3) SH2 domain, 4) EGFR Question 22 ( 6 points) Which three statements below describe why caspase proteases are the key mediators of the intrinsic cell death pathway, rather than some other class of proteins or biomolecules? Select 3 comect answer(s) Caspases are mitochondrial proteins that are released by TNF signaling, which is the cell death signal. Caspases have specific cleavage sites that target cellular proteins rather than other caspases. Caspases are catalytic enzymes and can degrade proteins quickly once activated. Caspases activate NFkappaB, which is the cellular death signal mediated by p50 and p 65. TNF receptors are activated by caspase binding, so it makes sense that caspases are "executioners." Caspase gene expression is regulated by cytochrome c binding to DNA to activate cell death. Cell viability require proteins and caspases destroy proteins, therefore the cell dies