Question 4

4. Label the compounds below as chiral or achiral. In addition, identify meso compounds where relevant. Crestor (Rosuvatatin) is a cholesterol biosynthesis inhibitor and is the top-selling pharmaceutical of the statin class of drugs (AstraZeneca sold \$6,620,000,000 in 2011 before it fell off patent and would have sold $0 if either or both of the stereogenic centers were inverted). Assign the stereochemistry of each stereogenic center in Crestor using the appropriate stereochemical descriptor (R/S)