QUESTION T In Drosophila melanogaster, loss-of-function mutations in either Pink1 or Parkin show similar phenotypes including...

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QUESTION T In Drosophila melanogaster, loss-of-function mutations in either Pink1 or Parkin show similar phenotypes including impaired ability to fly, male sterility, and degeneration of dopaminergic neurons. Transgenic overexpression of Parkin in mutants lacking Pinkt significantly ameliorates the loss-of-function phenotype, but overexpression of Pink1 cannot rescue the Parkin loss-of-function phenotype. According to these findings, which protein is more likely to act upstream of the other one? Assuming that the Parkin loss-of-function phenotype is merely due to defects in autophagy, would you expect Parkin overexpression to also rescue an ATG9 loss-of-function phenotype? Parkin acts upstream of Pink1; yes OParkin acts upstream of Pink1; no Pink1 acts upstream of Parkin; yes Pink1 acts upstream of Parkin; no QUESTION 8 How can the formation of tubular structures, as opposed to spherical vesicles, in the early endosomes facilitate recycling of membrane proteins such as cell-surface receptors? By increasing surface area-to-volume ratio By decreasing surface area-to-volume ratio By enhancing the formation of intralumenal vesicles By preventing the formation of intralumenal vesicles QUESTION 9 During maturation of early endosomes to late endosomes.... the vacuolar domain of the endosome is shed, whereas the tubular domain is retained. 3 the endosome migrates along actin filaments away from the cell interior the lumen of the endosome becomes more acidic. intralumenal vesicles disappear. All of the above. QUESTION 10 Insulin is a secretory protein made by the B cells in the pancreas. This protein... O is released by the B cells in response to increased intracelular Ca2+ concentration. is first synthesized as preproinsulin. madonna blackboard.com is stored as aggregates inside secretory vesicles in the cells. undergoes proteolytic cleavage before secretion. All of the above. Click Save and Submit to save and submit. Click Save All Answers to save all answers. $ 4 *5 % 6 & 7 8 9 Save All Answers BE 1p QUESTION T In Drosophila melanogaster, loss-of-function mutations in either Pink1 or Parkin show similar phenotypes including impaired ability to fly, male sterility, and degeneration of dopaminergic neurons. Transgenic overexpression of Parkin in mutants lacking Pinkt significantly ameliorates the loss-of-function phenotype, but overexpression of Pink1 cannot rescue the Parkin loss-of-function phenotype. According to these findings, which protein is more likely to act upstream of the other one? Assuming that the Parkin loss-of-function phenotype is merely due to defects in autophagy, would you expect Parkin overexpression to also rescue an ATG9 loss-of-function phenotype? Parkin acts upstream of Pink1; yes OParkin acts upstream of Pink1; no Pink1 acts upstream of Parkin; yes Pink1 acts upstream of Parkin; no QUESTION 8 How can the formation of tubular structures, as opposed to spherical vesicles, in the early endosomes facilitate recycling of membrane proteins such as cell-surface receptors? By increasing surface area-to-volume ratio By decreasing surface area-to-volume ratio By enhancing the formation of intralumenal vesicles By preventing the formation of intralumenal vesicles QUESTION 9 During maturation of early endosomes to late endosomes.... the vacuolar domain of the endosome is shed, whereas the tubular domain is retained. 3 the endosome migrates along actin filaments away from the cell interior the lumen of the endosome becomes more acidic. intralumenal vesicles disappear. All of the above. QUESTION 10 Insulin is a secretory protein made by the B cells in the pancreas. This protein... O is released by the B cells in response to increased intracelular Ca2+ concentration. is first synthesized as preproinsulin. madonna blackboard.com is stored as aggregates inside secretory vesicles in the cells. undergoes proteolytic cleavage before secretion. All of the above. Click Save and Submit to save and submit. Click Save All Answers to save all answers. $ 4 *5 % 6 & 7 8 9 Save All Answers BE 1p

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Answer 7 Pinkt acts upstream of Parkin This is because the overexpression of Parkin can rescue the l... View the full answer