[Questions 8-13] The image below shows a genome browser screen shot of the human KIT gene. Researchers are interested in understanding the role of KIT in the development of a tumor formation and cancer. People with KIT gene disruption have an increased lifetime risk of developing gastrointestinal cancer. The boxed region (black arrow) indicates a region of the genome that is duplicated in a tumor sample compared to normal tissue. Use this information to answer the following questions. 8. This duplication is not located in an intergenic region of the genome. a. True b. False

multi-region chr4:54.647.715-54.793,393 145,679 bp. gene, chromosome range, search terms, help pages, see exan 90 Examples chr4 (q12) 15.2 p15.1 p14 13 12 4 12 13.1 13.3 22. 4q24 4q25 4q26 q28.3 32.1 32.3 34.3 Scale 50 kb hg38 chr4: 54,700,000 54,750,000 Reference Assembly Fix Patch Sequence Alignments Reference Assembly Altemate Haplotype Sequence Alignments GENCODE V41 (23 items filtered out) KIT H3K27Ac Mark (Often Found Near Regulatory Elements) on 7 cell lines from ENCODE Layered H3K27Ac 100 vertebrates Basewise Conservation by PhyloP Cons 100 Verts Multiz Alignments of 100 Vertebrates Rhesus Mouse Rat Ell Pig Dog Elephant Zebra_finch Chicken X_tropicalis Zebrafish Lamprey