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The research question can be identified as: Is E-cigarette use associated with the incidence of respiratory compared to

non-use, independent of other tobacco products use? I do agree with the statistical methods. The advantages and disadvantages of statistical analysis methods depend heavily on the specific analysis used, the research question, and the data being analyzed. However, common advantages include the ability to quantify findings, identify trends, and make predictions, while disadvantages can include the potential for misinterpretation. Statistical analysis allows researchers to quantify observations and express findings numerically, adding a layer of objectivity to the research. A small or non-representative sample can limit the ability to generalize findings to the larger population. A small sample size may lack the statistical power to detect true effects, leading to a failure to reject a false null hypothesis. Maybe future research on e-cigarettes use could include nicotine and THC content, as well as flavors. And also explore the effects of dual use with combustible tobacco.