Scenario: A new study published in the Journal of the American Medical Association evaluated the effects...
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Scenario: A new study published in the Journal of the American Medical Association evaluated the effects of methylprednisolone, a cheap, widely used corticosteroid drug, as a treatment for IgA Nephropathy, an autoimmune disease that often results in the loss of kidney function up to and including kidney failure. Researchers recruited 553 patients who had been diagnosed with IgA Nephropathy from centers across Australia, Canada, China, India and Malaysia between May 2012 and November 2019. Patients were randomly enrolled into one of three groups, a group that received a dose of methylprednisolone daily, a group that received a half dose of methylprednisolone daily, or a placebo group. Clinicians who did know who was in which of the three groups tracked the kidney function of the patients. The group that received the full dose had a significant reduction in the risk of losing kidney function and kidney failure as compared to the placebo group. 1. Describe the treatment group(s). 2. What is the explanatory variable? 3. What were the results of the experiment? 4. Did the researchers use any blinding? If so, what was blinded? 5. Are the results generalizable to all adults with IgA Nephropathy? Explain your answer. Scenario: A new study published in the Journal of the American Medical Association evaluated the effects of methylprednisolone, a cheap, widely used corticosteroid drug, as a treatment for IgA Nephropathy, an autoimmune disease that often results in the loss of kidney function up to and including kidney failure. Researchers recruited 553 patients who had been diagnosed with IgA Nephropathy from centers across Australia, Canada, China, India and Malaysia between May 2012 and November 2019. Patients were randomly enrolled into one of three groups, a group that received a dose of methylprednisolone daily, a group that received a half dose of methylprednisolone daily, or a placebo group. Clinicians who did know who was in which of the three groups tracked the kidney function of the patients. The group that received the full dose had a significant reduction in the risk of losing kidney function and kidney failure as compared to the placebo group. 1. Describe the treatment group(s). 2. What is the explanatory variable? 3. What were the results of the experiment? 4. Did the researchers use any blinding? If so, what was blinded? 5. Are the results generalizable to all adults with IgA Nephropathy? Explain your answer.
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