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Chemistry Questions and Answers November 12, 2019

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An HPLC method was develop for the separation and determination of ibuprofen in rat plasma samples as part of a study of the time course of the drug in laboratory animals. Several standards were chromatographed and the following results obtained: Next, a 10 mg/kg sample of ibuprofen was administered orally to a laboratory rat. Blood samples were

Ibuprofen Concentration, mgmLPeak Area 0.5 5.0 1.0 10.1 2.0 17.2 3.0 19.8 6.0 39.7 8.0 57.3 10.0 66.9 15.0 95.3 ,Time, hr.Peak Area 0.5 91.3 1.0 80.2 1.5 52.1 2.0 38.5 3.0 24.2 4.0 21.2 6.0 18.5 8.0 15.2

At what temperature will a fixed mass of gas with a volume of 125 L at 15C and 750 mmHg occupy a volume of 101 L at a pressure of 645 mm Hg? a. 73C b. 10.4C c. 2C d. 34C e. 200C

Assuming the gas is either carbon dioxide, CO 2 , or methane, CH 4 , how many grams, will you need to fill a 250 mL flask? Even though these are not accurate, assume the following: Temperature is 25C Pressure is 1 atm Volume is 250 mL The gas is an ideal gas

Determine the heat absorbed by the calorimeter (gcal) and the heat capacity of the calorimeter (Ccal) for both trials you completed. Calculate the average qcal and Ccal for your calorimeter. The literature value for the heat of neutralization, i.e., the 11 reaction of HCI and NaOH, is reported as 56.2 kJmol. Calculate the molar heat of solution

Determine the molecular structure of this from the given IR, NMR, and Mass Spec data? Thank you!
Problem 97 IR Spectrum 1766 685 (KBr disc) 800 1600 200 4000 3000 2000 V (cm) 100 Mass Spectrum UV Spectrum 138 max 235 nm (log10& 4.1) 43 max 265 nm og108 3.0) 40 M 180 solvent ethanol 20 C9H8O4 40 80 120 60 200 240 280 m/e 13c NMR Spectrum 00.0 MHz, CDC3 solution) DEPT CH2 CH, CHA solvent proton decoupled 0 8 (ppm) 200 120 160 80 H NMR Spectrum 400 MHz, CDC solution expansion exchanges with D20 8.0 7.5 7.0 ppm 11.0 0.0 8,5 TMS 100 (ppm)

4000 100 80 60 40 20 IR Spectrum (KBr disc) of base peak him 40 exchanges with DO 10 13C NMR Spectrum (100.0 MHz, CDC), solution) 3000 DEPT CH CH CH www proton decoupled 43 H NMR Spectrum (400 MHz, CDCI, solution) 11.0 10.0 I 9 200 80 120 2000 121 I 8 1766 v (cm) 160 138 me 160 I 7 1685 1 1600 M 180 200 I 6 120 1 1200 14 8.5 8.0 7.5 expansion 240
Problem 97 IR Spectrum 1766 685 (KBr disc) 800 1600 200 4000 3000 2000 V (cm) 100 Mass Spectrum UV Spectrum 138 max 235 nm (log10& 4.1) 43 max 265 nm og108 3.0) 40 M 180 solvent ethanol 20 C9H8O4 40 80 120 60 200 240 280 m/e 13c NMR Spectrum 00.0 MHz, CDC3 solution) DEPT CH2 CH, CHA solvent proton decoupled 0 8 (ppm) 200 120 160 80 H NMR Spectrum 400 MHz, CDC solution expansion exchanges with D20 8.0 7.5 7.0 ppm 11.0 0.0 8,5 TMS 100 (ppm)

1. If instead of glycine, oxalic acid was titrated. How many equivalent points can be seen from the plot? 2. Manually sketch a titration curve for oxalic acid from a potentiometric titration of 20.0 mL of 0.10 M oxalic acid with 0.10 M NaOH. Identify the following in the titration curve: A) pK1 and pK2 B) equivalence points C) buffering regions