Question: Show R-code An article in Nature Genetics (2003, Vol. 34, pp. 85-90) Treatment-Specific Changes in Gene Expression Discriminate in vivo Drug Response in Human Leukemia

Show R-code An article in Nature Genetics (2003, Vol. 34, pp. 85-90) "Treatment-Specific Changes in Gene Expression Discriminate in vivo Drug Response in Human Leukemia Cells" studied gene expression as a function of different treatments for leukemia. Three treatment groups are: mercaptopurine (MP) only; low-dose methotrexate (LDMTX) and MP; and high-dose methotrexate (HDMTX) and MP. Each group contained ten subjects. The responses from a specific gene are shown in the table below: Treatments Subjects (Blocks) 1 2 3 4 5 6 7 8 9 10 MP ONLY: 1 334.5 31.6 701 41.2 61.2 69.6 67.5 66.6 120.7 881.9 MP + HDMTX: 2 919.4 404.2 1024.8 54.1 62.8 671.6 882.1 354.2 321.9 91.1 MP + LDMIX: 3 108.4 26.1 240.8 191.1 69.7 242.8 62.7 396.9 23.6 290.4 a. Is there evidence to support the claim that the treatment means differ? b. Check the normality assumption. Can we assume these samples are from normal populations? c. Take the logarithm of the raw data. Is there evidence to support the claim that the treatment means differ for the transformed data? d. Analyze the residuals from the transformed data and comment on model adequacy

Step by Step Solution

There are 3 Steps involved in it

1 Expert Approved Answer

Step: 1 Unlock blur-text-image

Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock

Step: 3 Unlock

Students Have Also Explored These Related Mathematics Questions!

It is wise to study anatomy alongside with physiology because it makes for more efficient use of students' and teachers' time physiology is only explainable in terms of the underlying anatomy anatomy...

An article in Nature Genetics (2003, Vol. 34, pp. 8590) Treatment-Specific Changes in Gene Expression Discriminate in vivo Drug Response in Human Leukemia Cells studied gene expression as a function...

An article in Nature Genetics (Vol. 34(1), 2003, PP 85-90), "Treatment-Specific Changes in Gene Expression Discriminate in Vivo Drug Response in Human Leukemia Cells," reported the study of gene...

4.12. An article in Nature Genetics (2003, Vol. 34, pp. 8590) Treatment-Specific Changes in Gene Expression Discriminate in vivo Drug Response in Human Leukemia Cells studied gene expression as a...

An article in Nature Genetics [(2003, Vol. 34(1)], Treatment-Specific Changes in Gene Expression Discriminate in vivo Drug Response in Human Leukemia Cells, reported the results of a study of gene...

An article in Nature Genetics (Vol. 34(1), 2003, pp. 8590), Treatment-Specific Changes in Gene Expression Discriminate in Vivo Drug Response in Human Leukemia Cells, reported the study of gene...

Montgomery 6.4.9 An article inNature Genetics["Treatment-specific Changes in Gene Expression Discriminate In Vivo Drug Response in Human Leukemia Cells" (2003, Vol. 34(1), pp. 85-90)] studied gene...

i need to describe about the gene data graphically and statically and report page and graphs and tables about the difference between the two data, the link for the data is attached below...

An article in Nature Genetics ("Treatment-specific Changes in Gene Expression Discriminate in Vivo Drug Response In Human Leukemia Cells" (2003, Vol. 34(1), pp. 85-90)] studied gene expression as a...

Under what conditions does there exist a linear function L: R2 R2 such that Under what conditions is L uniquely defined? In the latter case, write down the matrix representation of L. LG)-6) and...

What is the purpose of a credit memo?

Calculate the path integral C f ( x , y ) d s for the given function and path. f ( x , y ) = x y , r ( t ) = ( 5 t , 2 t - 5 ) for 0 t 1 ( E x p r e s s numbers i n exact form. Use symbolic notation...

What have households done to change or challenge the industrial food system? a. What are the changes in beef, chicken, hog, & corn industry?

The human resources aspect of Nursing Home Administration is integral to the success of the facility. Based on the text, summarize the key human resources functions. In your opinion, do you consider...

Gender ratingwhereby women pay the same premium as men A. makes the health insurance market similar to the auto insurance market. B. is fair because women incur the same medical costs as men do. C....

For the past five years Chu has been the New South Wales Operations Manager of Computers Pty Ltd, a company which retails computer software and hardware. Because of his senior position, Chu knows the...

(c) (10 marks) Show that the Fourier series (-1)" cos (nx) n2 n=1 converges uniformly on R to some function f and explain why f is continuous.

Data is absolutely central to this efficiency. Amazon gathers information on virtually everything its workers do from their pack rate to downtime then pits workers against each other on the basis of...

Always have the dignity of the other or others as a backdrop.

1. There are two purposes in this chapter. The first is to break out of habits that have a limiting effect on ones own ability to change. Secondly, it is to understand how the cleaning affects the...