Solve: Increased blood vessel formulation is a predictive factor in survival for a certain disease. One treatment is stem cell transplantation with the patient's own stem cells. The accompanying data table represents the microvessel density for patients who had a complete response to the stem cell transplant. The measurements were taken immediately prior to the stem cell transplant and at the time the complete response was determined. At the

0.01 level of significance, is there evidence that the mean microvessel density is higher before the stem cell transplant than after the stem cell transplant?

Let 1 be the mean density before the transplant and let 2 be the mean density after the transplant.

Patient	Before	After
1	177	286
2	196	231
3	206	113
4	361	256
5	420	309
6	400	167
7	411	264

The test statistic is tSTAT=