Systems thinking can provide a strong framework to comprehend and address complex issues of public health by highlighting interconnectedness and holistic perspectives, and applied to inform public health systems. This can include: (1) Understanding the issue through: (i) holistic perspectives - looking beyond the causes and effects and perceiving the larger contexts of a public health issue; (ii) interconnectedness - acknowledging that many distinct factors (i.e., environmental impacts, individual behaviors, and social determinants of health) can be interconnected and influence the outcomes of health; (iii) recognizing feedback loops - circular processes that can involve feedback to influence the original action to enhance or mitigate the outcome (Ashby et al., 2023). (2) Creation of interventions: (i) focusing on points of leverage - pinpointing certain areas within interventions could have the most influence; (ii) perceiving unintentional outcomes - expecting and minimizing probable unintentional outcomes of intervention across distinct parts of the system. (3) Assessing impact: (i) long-term perspectives - foster the examination of long-term outcomes of intervention; (ii) strategies of adaptation - promotion of a learning strategy involving continuous evaluation and adjustment of interventions based upon the observed system-wide changes (Ashby et al., 2023). Provide a public health example that illustrates the application of systems thinking