1) Show all disconnections, synthons, and functional group interconversions (FGI's). Several steps are required. Terfenadine is synthesized...
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Question:
1) Show all disconnections, synthons, and functional group interconversions (FGI's). Several steps are required.
Terfenadine is synthesized industrially from the amine 5, the acid chloride 6, and tertbutyl benzene 7. Apply the principles of retrosynthetic analysis to disconnect terfenadine 4 to these building blocks.
2) Outline the synthesis of terfenadine 4 from these building blocks, following the retrosynthesis you devised in part (i) above. Indicate any reagent(s) required at each step, and comment on any issues of selectivity.
Related Book For
Probability & Statistics for Engineers & Scientists
ISBN: 978-0130415295
7th Edition
Authors: Ronald E. Walpole, Raymond H. Myers, Sharon L. Myers, Keying
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