The calculation in Problem #$3$ was redone much later using the polar pathway extension to the UB$/$UC model $($Kasting et al$.,2019).$ Rather than embuing the polar pathway with water$-$like diffusivities $($as in modified Robinson$),$ the UB$/$UC model employs a cylindrical pore model with a pore radius of $16.$ Table $2$ shows the results. Using the UB$/$UC results, re$-$rank these compounds in terms of their likelihood of producing a bFGF release response in human skin. Provide your answer by identifying the top three candidates.

Table $2$

ID Class FWa, rsb$,$ Ddc$,$ kp$,$ Jss$,\%$ Abs Cbld$,$

Dalton $$ nM cm$/$h nmol$/$cm$2$h in $24$ h nM

I Hep disaccharide$14616\mathrm{.}84001\mathrm{.}12$E$-060\mathrm{.}120\mathrm{.}670\mathrm{.}76$

II Hep disaccharide$25637\mathrm{.}271502\mathrm{.}94$E$-070\mathrm{.}0260\mathrm{.}180\mathrm{.}19$

III Polysulfate$17948\mathrm{.}154002\mathrm{.}46$E$-070\mathrm{.}0150\mathrm{.}150\mathrm{.}14$

IV Polysulfate$211599\mathrm{.}242491\mathrm{.}81$E$-070\mathrm{.}0080\mathrm{.}110\mathrm{.}09$

V Polyamine $12009\mathrm{.}351301\mathrm{.}17$E$-070\mathrm{.}0050\mathrm{.}070\mathrm{.}057$

VI Polysulfonate $180010\mathrm{.}7901\mathrm{.}01$E$-070\mathrm{.}0030\mathrm{.}0610\mathrm{.}043$

VII GAG$1300012\mathrm{.}71\mathrm{.}64\mathrm{.}94$E$-080\mathrm{.}00080\mathrm{.}030\mathrm{.}017$

VIII GAG$2750017\mathrm{.}20\mathrm{.}31\mathrm{.}21$E$-080\mathrm{.}00010\mathrm{.}0070\mathrm{.}003$

IX Polysulfate$3800017\mathrm{.}61002\mathrm{.}13$E$-21000$

X GAG$31800023\mathrm{.}10\mathrm{.}0569\mathrm{.}80$E$-22000$

XI GAG$43600029\mathrm{.}10\mathrm{.}041\mathrm{.}19$E$-26000$

XII GAG$53600029\mathrm{.}10\mathrm{.}054\mathrm{.}78$E$-32000$

aFormula weight

bSolute radius calculated according to Mitragotri approximation, $4/3$ pr$3=0\mathrm{.}9087*$MW

cDoubling dose

dEstimated concentration at the basolateral membrane $($putative site of action$).$ Equivalent to Cbk in the class notes.

Group of answer choices

I, II$,$ III

III, IV$,$ VI

V$,$ IV$,$ III

VII, VIII, II

X$,$ XI$,$ XII