The company Hematech makes transgenic or genetically engineered cattle. Because of the genetic change that happens in genetic engineering....

$..$these Hematech cattle are a new species and would not be able to be crossed with non transgenic cattle.

$...$these Hematech cattle are not technically a new species but they would not be expected to produce fertile offspring when crossed with normal cattle because of the magnitude of the genetic change imposed by genetic engineering.

$...$the magnitude of genetic change in these transgenic cattle is relatively small and would not create a new species or interfere with the fertility of offspring.

$..$is not great in this case because the transgenic cattle have a knockout transgene but in other genetic engineering cases such as Bt corn or RR soybean where a new gene was added to the genome that encoded a new protein, the transgenic organism is a new species and genetic engineering created a reproduction barrier.