The concentration in the blood resulting from a single dose of drug normally decreases with time...

Transcribed Image Text:

The concentration in the blood resulting from a single dose of drug normally decreases with time as the drug is eliminated from the body. Doses may therefore need to be repeated periodically to keep the concentration from dropping below some particular level. One mode for the effect of repeated doses gives the residual concentration just before the (n+1)st dose as R, = C,e +Ce4 where C, the change in concentration achievable by a single dose (mg/mL), k =the elimination constant (h), and , time between the doses (h). See the figure below. G= C, + Coe"o C-1 RA R2 R = Coe kio Time (h) Concentration (mg/mL) A) Write R, in closed form as a single fraction, and find R= lim R. B) Calculate R, and R, for C, =1 mg/ml., k = 0.1h" and 1, = 10h. How good an estimate of R is R,? C) If k = 0.01h and t, = 10h, find the smallest n such that R, >(1/2)R. Use The concentration in the blood resulting from a single dose of drug normally decreases with time as the drug is eliminated from the body. Doses may therefore need to be repeated periodically to keep the concentration from dropping below some particular level. One mode for the effect of repeated doses gives the residual concentration just before the (n+1)st dose as R, = C,e +Ce4 where C, the change in concentration achievable by a single dose (mg/mL), k =the elimination constant (h), and , time between the doses (h). See the figure below. G= C, + Coe"o C-1 RA R2 R = Coe kio Time (h) Concentration (mg/mL) A) Write R, in closed form as a single fraction, and find R= lim R. B) Calculate R, and R, for C, =1 mg/ml., k = 0.1h" and 1, = 10h. How good an estimate of R is R,? C) If k = 0.01h and t, = 10h, find the smallest n such that R, >(1/2)R. Use

Answer rating: 100% (QA)

Answer Sel Grven that ... View the full answer