Question: The figure below has been reproduced from a 2 0 0 7 study conducted by researchers from University of Schleswig - Holstein ( Germany )
The figure below has been reproduced from a study conducted by researchers from University of SchleswigHolstein Germany and shows the resting membrane potential RMP of the atrium A and ventricle V of the heart of mice during early ED and late LD development. As you can see, there was a significant difference in RMP between ED and LD in both the atrium and ventricle, which the researchers showed could be entirely explained by differences in the activity of the sodiumcalcium exchanger NCX Given that NCX exchanges three Na ions for every one Ca ion, in which direction must the NCX operate during development in mouse hearts?
forward ie Na in Ca out
reverse ie out, Ca in
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