The following figure depicts the negative feedback loop used by the human body to maintain thermal homeostasis:

Discuss how heat stroke, acquired during extreme physical exercise, disrupts the feedback loop and the impact this disruption has on human physiology.

Sweat glands activate, increasing evaporative cooling Body temperature decreases, cooling mechanisms shut off Vessels constrict, reduce heat loss from skin Skeletal muscles shiver, generate heat Vessels dilate, increase heat loss from skin surface J The hypothalamus is the thermoregulating center of the brain. It strives to keep the body at its natural set point. Body temperature increases, warming mechanisms shut off