The $-$globin gene is poorly expressed in all $-$Thalassemia diseases. However, the cause of the disease can be due to a number of different mutations all resulting in a similar outcome $($anemia due to low levels of mature beta globin protein$).$ Certain subtypes of $$ Thalassemia arise from a single point mutation $($base pair change$)$ within the $-$globin gene. These mutations do not change amino acid sequence in the mature $-$globin protein. What are some possible reasons for the low level of $-$globin protein expression in these patients? There are $3$ possible reasons. Describe at least $2$ of the reasons.