Question: The interconversion rate for cis-trans X-Pro is 0.01 s. a) This rate is slow but much faster than for other peptide bonds not including Pro.

The interconversion rate for cis-trans X-Pro is 0.01 s. a) This rate is slow but much faster than for other peptide bonds not including Pro. Explain why. b) Calculate the activation free energy (AG+) for cis-trans X-Pro isomerization (we have not gone over this explicitly in class; this is a review question on kinetics, so you may need to consult your intro chem textbook or other resources). Use a value of the Arrhenius constant (pre-exponential factor) A = 8.00 x 1012 s- and a temperature T = 298 K. c) Using your answers in a) and b), draw a reaction coordinate diagram for the reaction: cis-X-Pro trans-X-Pro Recall this is a diagram of free energy vs. progress of the reaction, including the transition state
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