The pyridine N-oxide, compound A, is a new drug claimed to be useful for the treatment of
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The pyridine N-oxide, compound A, is a new drug claimed to be useful for the treatment of senile dementia. Industrial synthesis of it is outlined below.
i) Suggest a mechanism to account for Step 1 in the sequence.
ii) Suggest a mechanism to account for Step 2 in the sequence.
iii) Suggest a mechanism to account for Step 4 in the sequence.
iv) The oxidant used in Step 3 is the peroxy acid shown below. Why is hydrogen peroxide in acetic acid, the usual reagent for converting a pyridine into an N-oxide, not a good choice for the transformation shown in Step 3?
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Strategic Management Concepts and Cases
ISBN: 978-1118976586
1st edition
Authors: Jeffrey H. Dyer, Paul Godfrey, Robert Jensen, David Bryce
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