The structure of doxorubicin is shown below. This anticancer drug interacts with DNA to prevent replication...

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The structure of doxorubicin is shown below. This anticancer drug interacts with DNA to prevent replication and halt cancer cell division. The two essential features for the drug to exert its effect are the tricyclic ring system (highlighted in blue) and the protonated amine (highlighted in red). a. Predict how the tricyclic ring system would interact with DNA. b. An analog of this drug where the amino group has been replaced with a methoxy group (-OMe) shows poor activity. Explain this observation. OH OH ОН Н OH NH3 The structure of doxorubicin is shown below. This anticancer drug interacts with DNA to prevent replication and halt cancer cell division. The two essential features for the drug to exert its effect are the tricyclic ring system (highlighted in blue) and the protonated amine (highlighted in red). a. Predict how the tricyclic ring system would interact with DNA. b. An analog of this drug where the amino group has been replaced with a methoxy group (-OMe) shows poor activity. Explain this observation. OH OH ОН Н OH NH3