The U$.$S$.$ EPA is told that within the $45-$days of receiving a Pre$-$Manufacturing Notice $($PMN$)$ from their clients, they must do what? require client to manufacture and import a chemical allow sale and manufacture of a chemical regardless of its toxicity inf. send letters requiring no further testing or may prohibit temporarily Orequire immediate closure of chemical facility intending to produce it limit amount of chemicals to be produced, processed or prohibit selling.