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ezto.mheducation.com e Cell - Module 1 2 1 Saved Help Save Exit Sub Check my wor Sickle cell disease impact on circulatory system Complete the following paragraph to explain the physiological impact of sickle-cell disease on the circulatory system. a. The structure of ((Click to select) ) suits its function in gas exchange. Because red blood cells are responsible for delivering hemoglobin and oxygen to every cell of the body, any change in the ((Click to select) 9) of hemoglobin will change the ((Click to select) 9) of the red blood cell. b. With sickle cell disease, the hemoglobin in red blood cells is ((Click to select) 9) . This in turn changes the shape and damages the ((Click to select) 9) , the major type of cell in the circulatory system. c. Sickle red blood cells ((Click to select) .) together, blocking small blood vessels and causing painful and damaging problems. d. Sickle cell disease also prevents the hemoglobin in red blood cells from carrying ((Click to select) 9) to all parts of the body. As oxygen concentration of the body drops in the individual, a condition called ((Click to select) ) develops.