Question: This is the only information given, so please stop asking for more info. 2. Researchers were interested in a human syndrome characterized by short stature,

This is the only information given, so please stop asking for more info. This is the only information given, so please stop asking for more

2. Researchers were interested in a human syndrome characterized by short stature, hearing loss, premature aging and photosensitivity. Panel A shows the effect of UV on fibroblast survival. Panel B shows the effect of UV on lymphoblast replication. Panel C shows the effect of UV dose on unscheduled DNA synthesis (UDS), which is DNA synthesis that occurs at times other than S-phase. Ignore panel D. Based on these results, generate a possible hypothesis the molecular cause of this syndrome. Name one protein that could be involved and design experiment to test its involvement. Be sure to include appropriate controls. B 100 WT P3 0.8 10 0.6 % Survival relative to unirradiated > Population doublings in 72 h relative to unirradiated 0.4 X WT (L7) 0.2 L5 --L6 0 0 2 0.1 o 0 N 4 10 12 14 10 12 6 8 UV dose (J/m2 4 6 8 UV dose (J/m2) 140 120 WT P2 WI 100 P3 CS 80 UDS/cell (AU) 10000 9000 8000 7000 6000 5000 4000 3000 2000 1000 0 0 P2 P3 % RRS relative to unirradiated 0 60 40 20 0 2 10 12 0 5 15 20 4 6 8 UV dose (J/m) 10 UV dose (J/m)

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