Time left $0$:$24$:$10$Select the correct statement$/$statements regarding the signaling pathways involved in hormone action mediated by cell membrane receptors.I. Water$-$soluble hormones directly affect the transcription of target genes by binding to intracellular hormonereceptors$\mathrm{.}11.$ Steroid hormones bind to receptors located on the extracellular surface of the cell membrane and initiate a signaling cascade involving second messengers.III Not all water$-$soluble hormones initiate the cAMP second messenger system.IV$.$ The action of phosphodiesterase $($PDE$)$ ensures prolonged activation of the CAMP second messenger system by preventing the degradation of CAMP.Select onea II & IIIb. I & IIOnly IIId. I & IV