to $60m^3.$ The lab$-$scale bior the non$-$aerated CSTR from the lab scale of $03m^2$ impeller and operated at a rotar is installed with a single flat$-$blade turbine$-$type. large$-$scale bioreactors are geotational speed of $600rpm.$ The small$-$scale and is cultivated at both scales. The geomeally similar. $60\%$ of the total reactor volume between the tank and impeller diespect ratio must be kept at $1\mathrm{.}2,$ and the ratio viscosity of the culture broth are $1200$ must be maintained at $3.$ The density and

and $0\mathrm{.}1N.s.m^{-2}.$

lab scale

$($ii$)$ Estimate the $D_t,D_i,$ and $H_t$ for both small and large$-$scale bioreactors

$($iii$)$ Calculate the agitation rate for a large$-$scale bioreactor if the scale$-$up criterion is constant $\frac{P}{V}$

$($iv$)$ What are the protuberant Scale$-$up approaches that can be used, either together or separately, to sustain the performance of bioprocesses?