Question: Use the case below to answer Question 1 1 and 1 2 : A case - control study was conducted to assess the association of
Use the case below to answer Question and :
A casecontrol study was conducted to assess the association of breast cancer risk with oral contraceptive use. The investigators obtained a sample of women with breast cancer cases and matched them to a sample of women without breast cancer controls The investigators matched controls to case for a ratio of : All study participants were asked about their oral contracteptive use in the preceding years. The results of the study found an OR to ; for the risk of breast cancer with oral contraceptive use. However, the investigators are concerned about potential bias in their study. They believe the control group that they sampled had a lower degree of oral contraceptive exposure than the true source population. Assume that the true OR is to ;
Which of following strategies would have helped to minimize andor address this bias in the study?
Using standardized interview questionnaires to ask patients about their exposure to oral contraceptives.
Using prescription fill data instead of interviews to obtain information about their exposure to oral contraceptives.
Enrolling more controls into the study to ensure a control to case ratio of :
Carefully selecting controls to ensure they are from the same population that gave rise to the cases.
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