Use the NCBI website (https://www.ncbi.nlm.nih.gov/)

Answer the following questions: 1. Using the NCBI website (https://www.ncbl.nim.nih.gov/) to find answer for these questions: (1) What is the official gene symbol and official full name for the human SLC22A2 gone ? (2) What is the chromosome locus (location) of the human SLC2242 gene? (9) The gone SLC22A2 is mainly expression on (organ). 2. Open the RefSeq for the human SLC2242 mRNA and answer the following questions: (1) What is the size in base pairs (bp) of this mANA molecule of human SLC22A27 (2) Find the nucleotide locations of the start codon and stop codon for this gene, How many bp is the size of the open reading frame? (3) Find the position for all the exons of human SLC22A2 gene and show the nucleotide location in a table. Exons Start position End position Exon 1 Exon 2 Exon 3 Exon 4 Genetic analysis 3. Using the NCBI dbSNP database, browse the page showing all important SNPs located in the human SLC2242 gene. Is there any SNP with clinical significance? In the following table, selected SNPs in SLC2242 are shown. Fill in missing information for these SNPs: the numeric/alphabetic nomenclature for each of the SNPs; the mRNA positions; the minor allele frequency (MAF); The exons that these SNPs are located at (using results you obtained in question #2). The first SNP was done for you as an example. Ref Sequence: NM_003058.4 SNP ID (rs#) numeric/alph mRNA position MAF Exon Type abetic (NM_003058.4) (minor location nomenclature allele freq)(ALF A) rs139045661 C.1655TA 1655 0.00069 10 Missense (non- synonymous rs770994925 rs316003 rs201478523 rs8177517 rs8177516 rs316019 rs624249 Among these SNPs, if you can only choose one for further pharmacogenomic study, which one you would choose? Why