Use the sample data and confidence level given below to complete parts (a) through (d). A drug is used to help prevent blood clots in certain patients. In clinical trials, among 4949 patients treated with the drug, 184 developed the adverse reaction of nausea. Construct a 99% confidence interval for the proportion of adverse reactions. . . . a) Find the best point estimate of the population proportion p. (Round to three decimal places as needed.) b) Identify the value of the margin of error E. E= (Round to three decimal places as needed.) c) Construct the confidence interval.

0.22 O B. Ho: P = 0.22 H1 : p#0.22 O C. Ho: p = 0.22 H1: p