1. Using an appropriate statistical method evaluate the significance of difference in DBP between categories of smoking status. Utilise the SPSS generated statistical output relevant to this question available in the Appendix.
2. In a clinical trial, 35 subjects were treated with a new drug to show the efficacy of the drug. Their blood pressures
   

Independent Samples Test Levene's Test for Equality of Variances t-test for Equality of Means 95% Confidence Interval of the Mean Std. Error Difference F Sig. df Sig. (2-tailed) Difference Difference Lower Upper Diastolic Blood Pressure Equal variances 000 988 1.153 1417 249 709 .615 -.497 1.916 assumed Equal variances not 1.152 1140.524 249 709 .616 -.498 1.917 assumed60.00- 40.00 20.00- .00- difference Paired Samples Statistics Std. Error Mean N Std. Deviation Mean Pair 1 Baseline DBP 105.9714 35 13.86380 2.34341 End of Study DBP 81.0857 35 12.84150 2.17061Paired Samples Test Paired Differences 95% Confidence Interval of the Std. Error Difference Mean Std. Deviation Mean Lower Upper + df Sig. (2-tailed) Pair 1 Baseline DBP - End of Study DBP 24.88571 16.73104 2.82806 19.13840 30.63303 8.800 34 000Smoking status never smoked smoked 150 100 Frequency 50 0 40 60 80 100 120 40 60 80 100 120 Diastolic Blood PressureGroup Statistics Std. Error Smoking status N Mean Std. Deviation Mean Diastolic Blood Pressure never smoked 541 77.91 11.276 .485 smoked 878 77.20 11.241 .379