What are the primary considerations and challenges in the structural design of high$-$rise buildings in seismic$-$prone regions, and how do modern engineering practices address these issues? In your answer, explore the principles of earthquake$-$resistant design, including the concepts of base isolation, energy dissipation, and ductility. Discuss the importance of site$-$specific seismic hazard assessments and the integration of geotechnical and structural engineering to ensure building resilience. Evaluate the role of building codes and standards in guiding the design process and ensuring safety and performance. Additionally, consider the advancements in materials science, such as high$-$performance concrete and innovative steel alloys, and their impact on the structural integrity of high$-$rise buildings during seismic events. Reflect on the importance of interdisciplinary collaboration among architects, engineers, and seismologists, and how ongoing research and technological innovations continue to shape the future of earthquake$-$resistant building design.