Question: What is the effect on OCR and ECAR of adding DNP to the cell culture? DNP causes a decrease in OCR by inhibiting complex I
What is the effect on OCR and ECAR of adding DNP to the cell culture?
DNP causes a decrease in OCR by inhibiting complex I and an increase in ECAR by driving glycolysis.
DNP decreases OCR by inhibiting complex III, which increases ECAR from glycolysis to compensate.
DNP causes an increase in OCR by activating ATP synthase, which reduces ECAR by inhibiting glycolysis.
DNP increases OCR by uncoupling respiration from ATP synthesis, driving an increase in ECAR by activating glycolysis.
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