When a drug with one ionization center (which is characterized by its pKa) is dissolved in a
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Question:
When a drug with one ionization center (which is characterized by its pKa) is dissolved in a buffer solution (which is characterized by its pH), the relative concentration of its basic and acidic form can be calculated by the Henderson–Hasselbalch equation:
In the conditions as shown in the following table, please fill the blank cell with ionized, 50% ionized, neutral or 50% neutral according to the Henderson–Hasselbalch equation. (5 points)
Drug | pKa < pH - 2 | pKa = pH - 2 | pKa = pH | pKa = pH + 2 | pKa > pH + 2 |
Acidic | |||||
Basic |
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