Which molecule or structure has peptidyl transferase activity?

A$.$ DNA

B$.$ mRNA

C$.$ The large subunit of the ribosome

D$.$ tRNA

E$.$ The small subunit of the ribosome

People who are homozygous for the allele that encodes hemoglobin $S$ have sickle cell disease because this protein variant

A$.$ has a different charge.

B$.$ overproduces a substance.

C$.$ cannot produce an important metabolic substance.

D$.$ is a polypeptide.

E$.$ cannot break down a toxin.