Which statement about osteoblastic activity explains why osteoporosis commonly affects older adult patients more than younger ones? Select all that apply. One, some, or all responses may be correct.

Estrogen production increases with age.

Comorbidities tend to accumulate with age.

Normal aging often contributes to osteopenia.

Osteoblastic activity overtakes osteoclastic actions with increasing age.

Age$-$related illness may reduce weight$-$bearing activities.