Which statement is true about enzyme catalysis?

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A$)$ The substrate in an enzymatic reaction is referred to as the $$lock$.$

B$)$ The lock$-$and$-$key model of enzyme catalysis is a better model for explaining inhibitors.

C$)$ The active site is the region of the protein that directs the substrate to a nearby bonding site.

D$)$ Inhibitors can bind only at the enzyme$-$active site to prevent reaction from occurring.

E$)$ The induced fit model assumes that subtle changes mediated by substrate binding in the enzyme$-$active site creates a higher$-$energy transition state.