write a response to Acute inflammation and autoimmune disorders both involve the immune system but differ significantly in their pathophysiology, clinical presentation, and management. Acute inflammation is a protective, immediate response to injury or infection. In contrast, autoimmune disorders, such as rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), result from the immune system erroneously attacking the body's own tissues. The pathophysiology of acute inflammation involves vascular changes, increased blood flow, and the migration of white blood cells to the affected area. Chemical mediators like histamine, prostaglandins, and cytokines are released, triggering redness, heat, swelling, pain, and loss of function (Huether & McCance, 2020). This process is typically localized and resolves once the underlying cause is eliminated. Autoimmune disorders are chronic conditions characterized by a dysregulated immune response. In RA, for example, autoantibodies called rheumatoid factors attack the synovial membrane, leading to joint inflammation, pannus formation, and joint destruction. SLE involves the production of antinuclear antibodies that form immune complexes, affecting multiple organ systems (Mayo Clinic, 2023). Clinically, acute inflammation presents with the classic signs of swelling, heat, pain, and redness, typically at the site of injury. RA manifests as symmetrical joint pain, stiffness (especially in the morning), fatigue, and