You are looking under a microscope at different biopsied tissue samples from men with possible prostate cancer. You are asked to evaluate the properties of the possibly cancerous cells and provide the likelihood that the cancer has or will metastasize. What are the cell characteristics you expect for EMT and metastasis?

Tumor cell attachment to surrounding cells$/$tissues:

Cell adhesion molecule markers $($like cadherin$)$ and sticky$/$slippery:

Cell shape:

If obesity can create an environment for a tumor that can encourage EMT and invasion and metastasis without permanently mutating genes, is this an example of initiation, promotion, or progression?

Is there a drug that targets a single gene that can reduce or prevent EMT?