Question: You need to develop a direct compression tableted product that includes the following ingredients 20-30% Lactose fast flow 20-30% Avicel 101 60 mg API 1

You need to develop a direct compression tableted product that includes the following ingredients 20-30% Lactose fast flow 20-30% Avicel 101 60 mg API 1 (Acetaminophen) 5 mg API 2 (caffeine) 30 mg API 3 (Chlorpheniramine Maleate) 1 % MgSt Determine the answers to the following questions:

1. Propose a DOE to optimize formulation composition as an immediate release formulation. Justify.

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