Question: Your research group is working a polymer that can be used as a cell encapsulation device. Your lab works with glibenclamide:PEG and PVA polymers and

Your research group is working a polymer that can be used

Your research group is working a polymer that can be used as a cell encapsulation device. Your lab works with glibenclamide:PEG and PVA polymers and have determined the following diffusion coefficients (table below). Assuming you want a diffusion rate of 2.5X10-4 mol/(s cm2) and can reliably encapsulate 100k cells that will release 0.069 mol/cm3 and the thickness of your membrane 4 mm, which of the below polymers would you choose. Justify your response quantitatively, stating any assumptions you make. 1:1 Glibenclamide: Diffusion Glibenclamide: PEG ratio coefficient PVP ratio (cm sec) 1:1 5.96x104 1:3 1.5x10-3 1:3 1:5 2.32x103 1:5 1:7 4.5x103 1:7 PEG: Polyethylene glycol, PVP: Polyvinylpyrrolidone Diffusion coefficient (cm sec) 1.31x104 5.09x10-4 5.91x10-4 2.13x10-3 Your research group is working a polymer that can be used as a cell encapsulation device. Your lab works with glibenclamide:PEG and PVA polymers and have determined the following diffusion coefficients (table below). Assuming you want a diffusion rate of 2.5X10-4 mol/(s cm2) and can reliably encapsulate 100k cells that will release 0.069 mol/cm3 and the thickness of your membrane 4 mm, which of the below polymers would you choose. Justify your response quantitatively, stating any assumptions you make. 1:1 Glibenclamide: Diffusion Glibenclamide: PEG ratio coefficient PVP ratio (cm sec) 1:1 5.96x104 1:3 1.5x10-3 1:3 1:5 2.32x103 1:5 1:7 4.5x103 1:7 PEG: Polyethylene glycol, PVP: Polyvinylpyrrolidone Diffusion coefficient (cm sec) 1.31x104 5.09x10-4 5.91x10-4 2.13x10-3

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