Based on chemical equilibrium, obtain a general expression for dependence of the distribution coefficient of a weak base bioproduct B⁽²⁾ described by the equilibrium expression in Exercise 8.43 that interacts with an organic solvent extractant X⁽¹⁾ at the interface of an organic (1) Aqueous (2) System with valence z.

Data From Exercise 8.43

Derive general expressions for 

(a) The partition coefficient, K^o_D, in an organic (1) aqueous–(2) LLE system for an un-ionized (neutral) form of a weak base given by

and 

(b) The distribution coefficient between organic and aqueous fluid phases in terms of pH and pK_a.

Transcribed Image Text:

HB+ → H+ + B