Although methoxy is a strongly activating (and ortho, paradirecting) group, the meta positions in methoxybenzene (anisole) are

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Although methoxy is a strongly activating (and ortho, para–directing) group, the meta positions in methoxybenzene (anisole) are actually slightly deactivated toward electrophilic substitution relative to benzene. Explain. 

F (a) (b) (c) F F (d) -NO2 (e) -OCH3

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Organic Chemistry structure and function

ISBN: 978-1429204941

6th edition

Authors: K. Peter C. Vollhardt, Neil E. Schore

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