Suppose instead that the synonymous rate is three times that of the non synonymous rate Formally, n and s 3 Estimate , and compare with the values of found in Exercises 41 and 42 Mutation rates differ depending on whether changing the nucleotide base changes the amino acid (non synonymous sites) or...

The likelihood is the product of L s s from exercise 8141 and L n ...

Suppose instead that the synonymous rate is three times that of the non synonymous rate. Formally, n

Question:

Suppose instead that the synonymous rate is three times that of the non synonymous rate. Formally, λn = λ and λs = 3λ. Estimate λ, and compare with the values of λ found in Exercises 41 and 42.
Mutation rates differ depending on whether changing the nucleotide base changes the amino acid (non synonymous sites) or not (synonymous sites). A piece of DNA has 200 non synonymous sites with 12 mutations and 100 synonymous sites with 15 mutations. Our goal is to estimate the mutation rate.