Question: The amino acid methionine is formed by a methylthio reaction of homo?cysteine with N-methyltetrahydrofolate. The stereochemistry of the reaction has been probed by carrying out

The amino acid methionine is formed by a methylthio reaction of homo?cysteine with N-methyltetrahydrofolate. The stereochemistry of the reaction has been probed by carrying out the transformation using a donor with a ?chiral methyl group? that contains protium (H), deuterium (D), and tritium (T) isotopes of hydrogen. Does the methylation reaction occur with inversion or retention of configuration?

CO2 HS. CO2 Methionine synthase H3N H H3N H Homocysteine Methionine NHAI

CO2 HS. CO2 Methionine synthase H3N H H3N H Homocysteine Methionine NHAI H2N N-Methyltetrahydrofolate Tetrahydrofolate

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